How we read the research.

Every compound, supplement, and device on Protosi carries a badge describing the current weight of evidence. We use four categories:

Animal models

The vast majority of published research is in rats, mice, or other animal models. We use this tag when the peer-reviewed literature is dominated by preclinical work and human data is absent or limited to case reports.

In vitro

Studied primarily in cell culture and isolated tissue systems. Useful for mechanism research but furthest from clinical translation.

Human trials

Has been studied in randomized controlled trials or well-powered observational studies in humans. We do not distinguish between small pilots and large RCTs at the badge level — the profile text is where nuance lives.

Mixed evidence

Spans animal, in vitro, and limited human data — often with conflicting findings. A flag to read the profile carefully before drawing conclusions.

We use hedging language intentionally. Phrases we use:

Phrases we never use:

This is both a compliance requirement (therapeutic claims on non-FDA-approved research compounds are illegal) and an editorial principle — the actual science is more modest than the marketing. We try to match the literature.

Every compound profile includes a PubMed search URL. If the summary piques your interest, you can click through and read the primary literature yourself. We don't hide behind citations — we make them discoverable.

Where we cite specific studies in the future (blog posts, methodology deep-dives), we'll link directly to PubMed, DOI, or the publishing journal — never to a secondary aggregator.

Protosi is supported by affiliate relationships with suppliers we've vetted: peptide research vendors, third-party-tested supplement brands, device manufacturers, and lab-testing services. When you click a sourcing link and purchase, we earn a commission at no cost to you.

Every page with affiliate links carries an FTC disclosure at the top of the product section. We do not pretend our commercial relationships don't exist. We also don't let them change our research grading — an affiliate partner gets the same animal-models badge as a non-partner if that's what the literature supports.

We will never accept payment to publish content about a compound, supplement, or device. If you see a page, we wrote it because we thought the research was worth documenting.

The science changes. Our job is to keep up. When a compound moves from animal models to human trials, when new meta-analyses shift the weight of evidence, or when a supplier we recommend changes their sourcing — we update the profile and note the change date.

If you spot an error, we want to hear about it. Protosi gets better faster when readers push back on specific claims.

We cannot tell you whether a specific protocol is safe or appropriate for you personally. That's a clinical judgment that requires your full history, current labs, and a licensed practitioner who can take responsibility for the recommendation. Everything on Protosi is informational — a well-organized starting point for research, not a substitute for clinical care.